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AMG 330: an anti-CD33 bispecific T-Cell engager antibody construct in relapsed/refractory AML

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Published: 06.12.18
Views: 982

Prof Marion Subklewe - University of Munich, Munich, Germany

Prof Marion Subklewe speaks to ecancer at ASH 2018 about the phase 1 study into AMG330, an anti-CD33 bispecific T-Cell engager antibody construct, in relapsed/refractory AML.

She explains that the issue with the T cell antibody construct is cytokine release syndrome however these side effects were expected and dose steps were introduced in order to alleviate this.

Prof Subklewe reports that, although it is at an early stage, the study has seen some complete remissions in some of the higher doses.

ecancer's filming has been kindly supported by Amgen through the ecancer Global Foundation. ecancer is editorially independent and there is no influence over content.

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