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Inhibiting the immune system’s natural response may boost benefits and sustainability of CAR T therapy

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Published: 01.12.18
Views: 606

Dr Shannon Maude - Children’s Hospital of Philadelphia, Philadelphia, USA

Dr Shannon Maude speaks to ecancer at ASH 2018 about inhibiting the immune system’s natural response may boost benefits and sustainability of CAR T therapy.

She explains that the study investigated whether adding another immunotherapy agent to the CAR T-cell therapy regimen to prevent this effect could extend treatment response and improve outcomes for children with relapsed B-ALL.

Dr Maude reveals that in half of the patients who lost the CAR-T cells early on the combination of the reinfusion of CAR-T cells with PD-1 blockade extended the persistence.

Watch her press conference here.

Read the article here.

ecancer's filming has been kindly supported by Amgen through the ecancer Global Foundation. ecancer is editorially independent and there is no influence over content. 

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