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AURA 3: Mechanisms of osimertinib resistance in patients with EGFR T790M advanced NSCLC

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Published: 25.10.18
Views: 402

Dr Vassiliki A. Papadimitrakopoulou - University of Texas MD Anderson Cancer Center, Houston, USA

Dr Vassiliki A. Papadimitrakopoulou speaks with ecancer at the ESMO 2018 congress in Munich about an analysis of resistance mechanisms emerging in EGFR T790M advanced NSCLC patients treated with osimertinib.

Dr Papadimitrakopoulou outlines the genetic alterations detected in these patients, including a loss of T790 and a significant number showing MET amplification.

She also notes novel EGFR mutations and gene fusions, and considers alternative treatment schedules that may subvert these adaptations.

ecancer's filming has been kindly supported by MSD through the ecancer Global Foundation. ecancer is editorially independent and there is no influence over content.

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