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Early development in oncology: Are the MTD and monotherapy efficacy still the best objectives?

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Published: 06.07.18
Views: 390

Dr Giorgio Massimini - Merck KGaA, Germany

Dr Massimini speaks with ecancer at the 2018 WIN Symposium about drug development and whether we should still be aiming at maximum tolerability dose.

He suggests another endpoint could be the biological effective dose, when the dosage amount gives the best biological effect on the target.

Dr Massimini finally outlines the MERCURY trial which is an evolution of several other trials, and which will play close attention to the level of expression of the target in the normal tissue.

 

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