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Key developments in non-metastatic and metastatic hormone-sensitive prostate cancer

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Published: 04.06.18
Views: 3443

Dr Eleni Efstathiou, Prof Nicholas Mottet, Dr Andrew Armstrong and Prof Maria De Santis

Dr Eleni Efstathiou, Professor Nicholas Mottet, Prof Maria De Santis and Dr Andrew Armstrong discuss the latest data from ASCO 2018 for patients with hormone sensitive prostate cancer.

The group discuss a series of phase II trials, predictive biomarkers and signpost emerging therapies from the congress.  The discussion begins with reference to a Scandinavian adjuvant study (SPCG-13). Which was a randomised phase III trial between adjuvant docetaxel and surveillance after radical radiotherapy for intermediate and high risk prostate cancer. The group comments that the trial was negative and did not improve BDFS.

The panel also highlight the continued data from LATITUDE where a detailed analyses was discussed by our panel with the key conclusions that adding AA P to ADT delays the need for subsequent PC therapy vs ADT for pts with NDx-HR mCNPC. Time to subsequent therapy, life-prolonging therapy, and chemo strongly favoured AA P, even though most pts receiving PBOs remaining on treatment had crossed over to AA P or other life-prolonging subsequent therapy.

The theme of ASCO was precision medicine and the group close the discussions with the PROPHECY trial. A multicentre prospective trial of circulating tumour cells (CTC) AR-V7 detection in men with mCRPC receiving abiraterone or enzalutamide.

Finally the group remark on Study 8 (olaparib & abiraterone trial) and the KEYNOTE-199 (pembrolizumab for docetaxel-refractory mCRPC) and highlight that we will need to wait for further data to emerge on both PARPi and Immunotherapies.


SPCG-13 study of adjuvant docetaxel after radical radiotherapy
RTOG-0521 study of adjutant ADT in high risk prostate cancer
Treatment recommendations for high risk advanced disease
Long term followup from LATITUDE
Treatment choices for hormone naïve prostate cancer
Olaparib abiraterone acetate
Pembrolizumab efficacy in prostate cancer
PROPHECY study: predictive assays

This programme has been supported by an unrestricted educational grant from Janssen Pharmaceutica (A Johnson & Johnson Company).


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