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Results from the phase I ICONIC trial

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Published: 04.06.18
Views: 1000

Dr Timothy Yap - MD Anderson Cancer Center, Houston, USA

Dr Yap speaks with ecancer at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting about data from the ICONIC trial of ICOS agonist antibody JTX-2011, a first-in-class drug.

He outlines the mechanistic and pharmacodynamic rationale behind developing an ICOS agonist, and dosages in the ICONIC trial of JTX-2011 with or without nivolumab in advanced cancers.

Dr Yap highlights responses in gastric, breast and lung cancers, and introduces ongoing trials for JTX-2011 in combination with CTLA-4 checkpoint therapy.

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