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Durvalumab plus tremelimumab or durvalumab monotherapy in metastatic urothelial carcinoma

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Published: 09.02.18
Views: 502

Dr Guru Sonpavde - Dana-Farber Cancer Institute, Boston, USA

Dr Sonpavde speaks with ecancer at the 2018 ASCO Genitourinary Cancers Symposium about the STRONG trial, which will look at the use of of fixed-dose durvalumab tremelimumab or durvalumab monotherapy in advanced solid malignancies. 

He outlines that despite initial high response rates to current standard of care first-line chemotherapy, most patients with locally advanced or metastatic urothelial carcinoma eventually experience disease progression.

With no defined standard of care second-line therapies, prognosis remains poor, though immunotherapy offers hope.

When the durvalumab monotherapy cohort is established, the study will look at a fixed dose of durvalumab in combination with tremelimumab, also to be given at a fixed dose every 4 weeks.

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