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VinCaP: A phase II trial of vinflunine chemotherapy in locally-advanced and metastatic carcinoma of the penis

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Published: 09.02.18
Views: 414

Dr Lisa Pickering - The Royal Marsden NHS Foundation Trust, London, UK

Dr Pickering speaks with ecancer at the 2018 ASCO Genitourinary Cancers Symposium about the multicentre single-arm phase II VinCaP trial, looking into the use of of vinflunine chemotherapy in locally-advanced and metastatic carcinoma of the penis.

The trial of 25 patients delivered 4 cycles of chemotherapy.

The trial exceeded it's primary endpoint (of 7 patients) with 10 patients showing stable disease or objective response.

The toxicities reported were neutropenia, anaemia and sepsis. 

Overall it was a successful study since some patients who were previously deemed unsuitable for combination chemotherapy were able to receive this form of chemotherapy.

Due to the rarity of penis cancer, there have only been small studies to date, so this is an emerging field.

To get a large enough patient group for a randomised trial, we would need to be looking on a global level. 

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