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The European Prospective Investigation into Cancer and Nutrition

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Published: 22.09.17
Views: 646

Dr David Hughes - Conway Institute, University College Dublin, Ireland

Dr David Hughes talks to ecancer at the Microbiome in Cancer and Beyond 2017 meeting about EPIC (European Prospective Investigation into Cancer and Nutrition) which studies a large number of Europeans from a healthy status through to the development of cancer. This allows for the comparison between cancer patients and healthy individuals who do not contract the disease.

The primary focus was to study the nutrition of these individuals, with the study being further developed into many new areas. Important metabolites were highlighted such as short chain fatty acids which protect against cancer. Dr Hughes explains that a Western diet with high levels of red meat causes a dysbiosis in the gut microbiome and production of carcinogens.

New data from EPIC concerns Streptococcus gallolyticus, with high presence in cancer patients, supported by its previous involvement in cancer using animal models. Furthermore, the antigens for this bacterium are present in healthy individuals.

Dr Hughes encourages the discussion of prevention of dysbiosis in the microbiome, rather than treatment. This will focus on diet and probiotics. 

He finally touches upon the current debate concerning Fusobacterium nucleatum which is has increased tissue presence in colorectal cancer. His impression is that it is more involved with the progression of colorectal cancer as opposed to intiation, and thus the functionality of microbes is more improtant than presence or abundance.

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