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Genetic determinants of breast cancer immune phenotypes

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Published: 12.05.17
Views: 728

Dr Giuseppe Curigliano - European Institute of Oncology, Milan, Italy

Dr Curigliano speaks with ecancer at IMPAKT 2017 about predicting patient response to checkpoint immunotherapy through genetic screening.

He introduces a patient subpopulation with an overexpression of Immunologic Constant of Rejection (ICR) within HER2 /triple negative breast cancer who are most responsive to immunotherapy.

Dr Curigliano highlights that these tumour subtypes are also most often associated with tumour infiltration by lymphocytes, and that this stratification of response could help in selecting treatments for patients.

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Cancer Intelligence