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Targeting tumour vasculature by DNA vaccines

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Published: 01.04.16
Views: 1378

Dr Andrea Facciabene - University of Pennsylvania, Philadelphia, USA

Dr Facciabene (University of Pennsylvania, Philadelphia, USA) talks to ecancertv at ITOC3 about novel TEM-1 vaccines.

The vaccine targets Tumour Endothelial Marker 1, eliminating tumour vasculature and inducing a secondary immune response.

The trials have proven effective in models of breast cancer, Lewis lung carcinoma, cervical cancer and colorectal cancer.

Host angiogenesis in wound healing and pregnancy is unaffected by the vaccine.

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