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Idelalisib and rituximab for previously treated chronic lymphocytic leukaemia (CLL)

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Published: 17.12.13
Views: 4051

Dr Richard Furman - New York Weill Cornell Medical Center, USA

Dr Furman talks to ecancertv at ASH 2013 about his study: "A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Idelalisib and Rituximab for Previously Treated Patients with Chronic Lymphocytic Leukemia (CLL)"

Idelalisib (IDELA) is a first-in-class, selective, oral inhibitor of PI3Kδ that reduces proliferation, enhances apoptosis, and inhibits homing and retention of malignant B cells in lymphoid tissues.

This Phase 3 study evaluated the efficacy and safety of Idelalisib plus rituximab vs placebo plus retuximab in patients with previously treated CLL.

Idelalisib plus rituximab demonstrated statistically significant improvement with acceptable safety over placebo plus rituximab in PFS, ORR, LNR and OS in heavily pretreated patients with relapsed CLL, including those with adverse genetic features.


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