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Recent advances in advanced melanoma: ipilimumab (2/6)

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Published: 15.08.11
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European Post ASCO Meeting 2011 - Prof Axel Hauschild, Prof Michele Maio, Prof Paul Lorigan, Prof Dirk Schadendorf

Research presented at the 2011 ASCO congress has demonstrated that the anti-CTLA4 antibody ipilimumab improve overall survival in both previously untreated melanoma patients and those receiving second line therapy. Ipilimumab acts by reducing natural inhibition of the immune system, causing the body to attack cancer cells more aggressively. This allows the body to stabilise the disease and prevent tumour growth. These effects are targeted at the immune system and consequently the associated adverse effects are quite different to those caused by drugs which target cancer cells. The panel outline the side effects seen in patients treated with ipilimumab, explain how clinicians have learnt to manage these effects and discuss how cost is likely to affect the chance of ipilimumab approval in various European countries.

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