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New oncogene target for breast cancer: LMTK3

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Published: 22.06.11
Views: 7814
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Prof Justin Stebbing - Imperial College London, UK

Prof Justin Stebbing discusses his research which identified a new protein involved in the development of drug resistance in breast cancer. It is hoped that this can ultimately be used as a target for new treatments. In the study, researchers from Imperial College London found that blocking a protein called LMTK3 in human cancer cells that were resistant to tamoxifen made the cells more responsive.

 

Prof Stebbing explains how this protein was identified and talks about the other research he was presenting at the ASCO meeting. This research included the results of a study investigating the links between weight gain and poor response to chemotherapy, a paper on circulating tumour cells in prostate cancer and a presentation looking at polymorphism in the IGFR1 gene as a predictive factor for patient outcome.

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