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Cancer riddle, solved

Cancer is a mysterious disease for many reasons.

Chief among the unknowns are how and why tumours form.

Two University of Iowa studies offer key insights by recording in real time, and in 3-D, the movements of cancerous human breast tissue cells.

It's believed to be the first time cancer cells' motion and accretion into tumours has been continuously tracked.

The team discovered that cancerous cells actively recruit healthy cells into tumours by extending a cable of sorts to grab their neighbors--both cancerous and healthy--and reel them in.

Moreover, the Iowa researchers report that as little as five percent of cancerous cells are needed to form the tumours, a ratio that heretofore had been unknown.

"It's not like things sticking to each other," said David Soll, biology professor at the UI and corresponding author on the paper, published in the American Journal of Cancer Research.

"It's that these cells go out and actively recruit. It's complicated stuff, and it's not passive. No one had a clue that there were specialised cells in this process, and that it's a small number that pulls all the rest in."

The findings could lead to a more precise identification of tumourigenic cells (those that form tumours) and testing which antibodies would be best equipped to eliminate them.

Soll's Monoclonal Antibody Research Institute and the Developmental Studies Hybridoma Bank, created by the National Institutes of Health as a national resource, directed by Soll and housed at the UI, together contain one of the world's largest collections of antibodies that could be used for the anti-cancer testing, based on the new findings.

In a paper published last spring in the journal PLOS One, Soll's team showed that only cancerous cells (from a variety of cancers, including lung, skin, and aggressive brain tumours known as glioblastomas) engaged in tumour formation by actively soliciting other cells.

Like evil-minded envoys, individual cancer cells extend themselves outward from the original cluster, probing for other cells in the area, the researchers observed.

Once it detects one, the extended cell latches on and pulls it in, forming a larger mass.

The activity continues, the cancerous extensions drawing in more and more cells--including healthy cells--as the tumour enlarges.

"There's nothing but tumourigenic cells in the bridge (between cells)," Soll said, "and that's the discovery. The tumourigenic cells know what they're doing. They make tumours."

The question is how these cells know what to do.

Soll hypothesises they're reaching back to a primitive past, when these cells were programmed to form embryos.

If true, perhaps the cancerous cells--masquerading as embryo-forming cells--recruit other cells to make tissue that then forms the layered, self-sustaining architecture needed for a tumour to form and thrive.

Think of a Death Star that's built up enough defenses to ward off repeated attacks.

Or, less figuratively, how bacteria can conspire to create an impenetrable film on surfaces, from orthopedic implants to catheters.

"There must be a reason," Soll said.

"You might want one big tumour capable of producing the tissue it needs to form a micro-environment. It's as if it's building its own defenses against the body's efforts to defeat them."

In the AJCR paper, the researchers compared the actions of human breast tissue cells (MoVi-10') to a weakly tumourigenic, parental breast cancer cell line (MCF-7).

First, they found that over a 50-hour period, MoVi-10'-only cells grew more in density, primarily by joining together, than did MCF-7.

Also, in all instances, regardless of the ratio of MCF-7 to MoVi-10' cells in the cluster, only MoVi-10' cells reached out and drew in other cells--including healthy cells--to the growing mass.

"The results here extend our original observation that tumourigenic cell lines and fresh tumour cells possess the unique capacity to undergo coalescence through the active formation of cellular cables," the authors write.

The finding lends more weight to the idea that tumours are created concurrently, in multiple locations, by individual clusters of cells that employ the cancer-cell cables to draw in more cells and enlarge themselves.

Some have argued that tumours come about more by cellular changes within the masses, known as the "cancer stem cell theory."

Soll's team also discovered that the Mo-Vi10' cells move at 92 microns per hour, about twice the speed of healthy cells.

That's important because it helps scientists better understand how quickly tumours can be created.

Source: The University of Iowa



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