Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   

Less radical procedures offer similar cancer control for kidney cancer patients

Needle-guided tumour destruction procedures offer near equivalent lengths of local cancer control compared to surgery for patients with small kidney cancer tumours, according to the results of a large study published in European Urology.

"If validated, these data suggest that an update to clinical guidelines would be warranted," says the study's lead author, R. Houston Thompson, M.D., a Mayo Clinic urologist.

Dr. Thompson says radical nephrectomy – surgical removal of the entire kidney – has historically been the standard of care for management of kidney cancer; however, partial nephrectomy – surgical removal of tumours from a kidney while sparing healthy tissue –has become increasingly more common because of its nephron-sparing benefits and similar cancer control.

The nephron is the part of the kidney that filters out toxins from the blood.

"We undertook this study because direct comparisons of outcomes among patients with kidney cancer who have received partial nephrectomy (PN), radiofrequency ablation (RFA) – tumour destruction using intense heat and cryoablation – tumour destruction using extreme cold – are lacking, especially from institutions that routinely perform all three of these procedures," Dr. Thompson says.

Researchers studied a total of 1,803 patients.

Among patients with tumours 4 cm or less, 1,057 patients received PN, 180 received RFA and 187 received cryoablation.

Recurrence-free survival was similar among the three treatment groups, while metastases-free survival was significantly better for patients who received PN and cryoablation when compared with patients who received RFA.

For the 379 patients with 4 cm tumours, lengths of recurrence-free and metastases-free survival were similar between PN and cryoablation.

In that group, 326 underwent PN and 53 received cryoablation.

"Cryoablation and RFA have traditionally been thought to provide inferior outcomes compared with surgical removal. Our results of near equivalent success, if correct, should encourage further investigation of these treatment modalities among patients with early stage kidney cancer," Dr. Thompson says.

Source: Mayo Clinic

0

Comments

Please click on the 'New Comment' link to the left to add a new comment, or alternatively click any 'Add Comment' link next to any existing post to respond. The views expressed here are not those of ecancer. For more information please view our Privacy Policy.



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation