Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   

Cell division at high speed

In malignant tumours, the cells usually proliferate quickly and uncontrollably.

A research team from the Biocenter of Julius-Maximilians-Universität (JMU) Würzburg in Bavaria, Germany, has discovered that two important regulators of cell division can interact in this process.

If this is the case, affected patients have particularly poor chances of survival.

A special form of lung cancer was investigated.

The JMU team led by Professor Stefan Gaubatz and Dr Grit Pattschull from the Chair of Biochemistry and Molecular Biology II analysed the activities of the protein YAP and the protein complex MMB (Myb-MuvB).

According to the researchers, the former protein is only able to initiate cell division when it interacts with a subunit of the MMB complex.

The molecular details of these processes are currently described in the journal Cell Reports.

"Our results show for the first time that there is a connection between these two cancer-relevant signalling pathways," said Professor Gaubatz.

If this connection can be broken, this could possibly be applied for cancer therapy.

Next, the JMU research team will investigate the exact details of the interaction between YAP and the MMB protein complex.

In particular, the researchers hope to identify further proteins that are involved in the interaction of the two signalling pathways.

The long-term goal is to suppress tumour growth by blocking the interaction.

Source: University of Würzburg

Image Credit: AG Gaubatz, University of Würzburg

0

Comments

Please click on the 'New Comment' link to the left to add a new comment, or alternatively click any 'Add Comment' link next to any existing post to respond. The views expressed here are not those of ecancer. For more information please view our Privacy Policy.



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation