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Blood cells could hold master clock behind ageing

Blood cells could hold the key to ageing, according to a study published in the journal Aging Cell.

Researchers found human blood cells have an intrinsic clock that remains steady even after a transplant.

It has also been suggested that the clock could control human ageing and may underlie blood cancers.

Shigemi Matsuyama, cell biologist and associate professor of medicine at Case Western Reserve University School of Medicine, led an international team of researchers in studying the clock.

The team measured cellular age in blood cells transplanted from healthy donors to leukaemia patients, focusing on donor-recipient pairs of very different ages.

"This study is related to the fountain of youth," Matsuyama said. "We found young blood cells stay young in older people. There was no accelerated ageing of young blood cells in an older human body."

Matsuyama's team found the other direction was also true - blood cells from adult donors transferred to a child stay older.

The cells retained their intrinsic age nearly two decades after the transplant.

Their inherent steadiness suggests blood cells could be the master clock of human ageing, as they are not easily influenced by their environment, Matsuyama suggested.

The study showed blood cells retain epigenetic patterns in DNA methylation - which is a process where chemical (methyl) groups become attached to DNA.

Therefore, these epigenetic changes can be used to calculate their age.

Despite substantial age differences between the donor and the recipient (up to 49 years), the DNA methylation age of transplanted blood reflected the age of the donor - even after many years of exposure to the recipient's body.

Matsuyama also added, "DNA functions as a timekeeper of our age."

DNA methylation as a predictor of age was first described in 2013 by Matsuyama's collaborator on the study, biostatistician Steve Horvath, of the University of California, Los Angeles.

"He found the formula. The mechanism, and whether cells in the body synchronise DNA methylation age, wasn't clear," Matsuyama explained. "I'm not a mathematician. I'm a cell biologist. So, we collaborated to investigate the mechanism of the epigenetic clock in an experimental system in my lab."

Matsuyama tested blood samples collected regularly as part of transplant monitoring.

He expanded his sample repository via leukaemia researchers at the University of Oslo, in Norway, who heard about his work at the 2016 Keystone Symposia on ageing.

Horvath crunched cellular ages using 353 distinct methylation sites found on blood cell DNA.

Together, the researchers provided the first experimental evidence that the ageing clock of blood cells is cell-intrinsic and not set by interactions with other cell types in the body.

They are now working to identify mechanisms that can change the clock.

"In cancer cells, the clock is broken," Matsuyama said. "DNA methylation patterns are unstable in cancerous blood cells and often show odd ageing. For example, they can be 200 or 5 years old in a 50-year-old patient. It does not match at all with the actual age."

Matsuyama cautions that this is why, although it may sound appealing, he doesn't yet recommend "therapeutic" cell infusions to try to maintain one's youth.

"We don't know if blood cells serve as a master clock that could synchronise other cells. We just don't know yet," he said.

Instead, Matsuyama's team is working to understand why epigenetic age differences exist in cancer cells, and how they could be overcome.

"It may be by turning on or off certain genes within the cells, we can reset the clock," Matsuyama stated. 

Recent studies show the DNA age of human cells can be used as a biomarker to predict the risk of age-associated diseases, such as Alzheimer's disease, cardiovascular disease, and others.

Last year, Horvath and Matsuyama helped publish an article reporting that DNA age is significantly accelerated in Progeria patients who suffer from premature ageing.

Matsuyama and his colleagues now have several studies underway to uncover the mechanism of age-dependent DNA methylation, and to understand how factors such as diet, exercise, and oxygen levels influence epigenetic clocks.

Source: Case Western Reserve University



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