My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 9 597 / https://doi.org/10.3332/ecancer.2015.597

Special Issue

Chemoprevention studies within lung cancer screening programmes

While aggressive tobacco control and help to stop smoking are essential weapons in the fight against lung cancer, screening with low-dose computed tomography (LDCT) in high-risk populations and chemoprevention may also contribute to reducing lung cancer deaths. Persons undergoing LDCT screening are an ideal population to be tested for agents potentially able to prevent the development of lung cancer by the regression of precancerous lesions, which are routinely monitored as part of the screening process. Peripheral subsolid nodules appear as particularly suitable targets, since many are adenocarcinoma precursors.

A study on inhaled budesonide (a potential chemopreventive drug) for 1 year found that the mean size of non-solid lung nodules was significantly reduced over 5 years of follow-up, compared to inhaled placebo, in a population of high-risk individuals with indeterminate lung nodules not requiring immediate specific investigation for lung cancer and detected as part of a lung cancer screening program with LDCT.

A new randomised placebo-controlled phase-II trial to test the ability of aspirin to induce the regression of non-solid and partially solid nodules detected by LDCT screening has been started. The effect of aspirin on a miRNA signature able to predict the presence of both cancer and precancerous lesions in high-risk asymptomatic individuals is also being monitored in the trial. This signature was previously shown to predict the presence of both lung cancer and non-solid lung nodules in asymptomatic individuals.

Keywords: chemoprevention, GGO, lung cancer, screening

Loading Article Metrics ... Please wait

Author interviews

Giulia Veronesi

European Institute of Oncology, Milan, Italy

Related videos

Related articles

Conference Report: Highlights from the 10th Breast, Gynaecological and Immunotherapy International Cancer Conference (BGICC), 18–19 January 2018, Cairo, Egypt

Abstract | Full Article | PDF Published: 22 Mar 2018 / https://doi.org/10.3332/ecancer.2018.820

Review: Cystic brain metastases in ALK-rearranged non-small cell lung cancer

Abstract | Full Article | PDF Published: 14 Mar 2018 / https://doi.org/10.3332/ecancer.2018.818

Short Communication: InforMD: a new initiative to raise public awareness about breast density

Abstract | Full Article | PDF Published: 06 Feb 2018 / https://doi.org/10.3332/ecancer.2018.807

Research: Knowledge and attitude of women regarding breast cancer screening tests in Eastern Iran

Abstract | Full Article | PDF Published: 05 Feb 2018 / https://doi.org/10.3332/ecancer.2018.806

Research: Diagnostic validity of fine-needle capillary cytology in palpable tumours at the Oncology Institute of Peru

Abstract | Full Article | PDF | Spanish Published: 01 Feb 2018 / https://doi.org/10.3332/ecancer.2018.805



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence