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Abstract | Full HTML Article | PDF ecancer 6 241 / https://doi.org/10.3332/ecancer.2012.241

Visions

Tumor-infiltrating granulocytic cells promote cancer cell dissemination

Most studies aimed at understanding the link between inflammation and cancer progression have focused on macrophages. In a recent study published in PLoS Biology, Toh B et al (2011) Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor PLoS Biol 9 e1001162, we show that a subset of granulocytic cells already known to suppress antitumour immune responses also promotes cancer cell proliferation and metastasis by inducing epithelial to mesenchymal transition. This subset plays a key role in early dissemination of cancer cells throughout the body and may therefore represent a novel target for therapeutic intervention.

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Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation