Abstract | Full HTML Article | PDF ecancer 3 145 / https://doi.org/10.3332/ecancer.2009.145

Cell-cell fusion as a potential target in cancer therapy

JM Gasent-Blesa and VA Candel

In the fight against cancer, new and more specific targets are needed. Here, we offer an example of a potential target that has not been widely studied, namely the syncytin protein. Syncytin is expressed mainly in the human placenta and is implicated in placental syncytiotrophoblast cell fusion. Not much is known about the role of syncytin in cancer, but the existing data call for more intense research. Its retroviral origin and particular tissue distribution make syncytin an interesting potential target in cancer therapy.