Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 12 866 / https://doi.org/10.3332/ecancer.2018.866

Special Issue

Lung cancer: a new frontier for microbiome research and clinical translation

The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome.

Keywords: lung cancer, microbiome, Granulicatella, ATP

Categories:

Lung & pleura

Loading Article Metrics ... Please wait

Related articles

Case Report: Use of PEG-asparaginase in a case of Hepatosplenic γδ T-cell lymphoma with long-term remission after stem cell transplantation

Abstract | Full Article | PDF Published: 20 Sep 2018 / https://doi.org/10.3332/ecancer.2018.872

Conference Report: Highlights from the 2018 WIN Symposium, 25–26 June 2018, Paris: designing the future of precision oncology

Abstract | Full Article | PDF Published: 12 Sep 2018 / https://doi.org/10.3332/ecancer.2018.871

Conference Report: Inspiration, innovation and integration: highlights from the third ICPCN conference on children’s palliative care, 30th May-2nd June 2018, Durban, South Africa

Abstract | Full Article | PDF Published: 11 Sep 2018 / https://doi.org/10.3332/ecancer.2018.870

Special Issue: Pre-, pro- and synbiotics in cancer prevention and treatment—a review of basic and clinical research

Abstract | Full Article | PDF Published: 05 Sep 2018 / https://doi.org/10.3332/ecancer.2018.869

Special Issue: Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment

Abstract | Full Article | PDF Published: 05 Sep 2018 / https://doi.org/10.3332/ecancer.2018.868



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation