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Abstract | Full HTML Article | PDF ecancer 11 787 / https://doi.org/10.3332/ecancer.2017.787

Special Issue

Non-small cell lung cancer treatment (r)evolution: ten years of advances and more to come

Diagnostic and treatment algorithms in non-small cell lung cancer (NSCLC) are evolving at a never-before-seen pace. Histological subtyping to maximise treatment efficacy and avoid toxicity has marked the beginning of the revolution, opening the way to molecular characterisation to guide genomically driven treatments with targeted agents, led by an Epidermal Growth Factor Receptor (EGFR) and Anaplastic Lymphoma Kinase (ALK) inhibitors. More recently, agents against the Program Death 1 receptor (PD-1) and ligand 1 (PD-L1) have entered the clinical arena, offering new hope to NSCLC patients, although several uncertainties remain to be elucidated. Here, we review the most clinically relevant advances in the diagnosis and treatment of NSCLC in the past decade.

Keywords: non-small cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), program death 1 receptor (PD-1), checkpoint inhibitors

Categories:

Lung & pleura

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Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation