Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 11 782 / https://doi.org/10.3332/ecancer.2017.782

Special Issue

Acute myeloid leukaemia at an early age: Reviewing the interaction between pesticide exposure and KMT2A-rearrangment

Acute myeloid leukaemia (AML) in early childhood is characterised by a high frequency of recurrent genomic aberrations associated with distinct myeloid subtypes, clinical outcomes and pathogenesis. Genomic instability is the first step of pathogenic mechanism in early childhood AML. A sum of adverse events is necessary to the development of infant AML (i-AML), which includes latency of biochemical-molecular and cellular effects. Inherited genetic susceptibility associated with exposures to biotransformation substances can modulate the risk of DNA damage and it is a very important piece in the pathogenic puzzle. In this review, we have aimed to explore the chain of events in the time-points of the natural history of i-AML, which includes maternal exposures during pregnancy, the speculations about the formation of somatic mutations during foetal life and the secondary genomic aberrations associated with i-AML. The modulation of risk conferred by xenobiotic metabolism´s genes variants is the bottom line of the pathogenic process. Since we have conducted observational and molecular investigations in early childhood leukaemia, the data focused here is based on Brazilian findings with summarised results of our experience with epidemiological and molecular studies in early-age leukaemia.

Keywords: acute myeloid leukaemia, KMT2A-rearrangements, pesticides maternal exposure, gene polymorphisms

Loading Article Metrics ... Please wait

Related articles

Conference Report: From science to real-life oncology—the ECCO 2018 European Cancer Summit, 7–9 September 2018, Vienna, Austria

Abstract | Full Article | PDF Published: 15 Oct 2018 / https://doi.org/10.3332/ecancer.2018.877

Research: Thromboembolic events in patients with advanced stage non-small cell lung cancer treated with platinum-based chemotherapy: a prospective observational study

Abstract | Full Article | PDF Published: 09 Oct 2018 / https://doi.org/10.3332/ecancer.2018.876

Short Communication: Regorafenib adjusted dose for Chilean patients with chemoresistant metastatic colorectal cancer: a case series

Abstract | Full Article | PDF Published: 02 Oct 2018 / https://doi.org/10.3332/ecancer.2018.875

Review: Clinical decision making in postmastectomy radiotherapy in node negative breast cancer

Abstract | Full Article | PDF Published: 26 Sep 2018 / https://doi.org/10.3332/ecancer.2018.874

Research: What information do cancer patients want and how well are their needs being met?

Abstract | Full Article | PDF Published: 25 Sep 2018 / https://doi.org/10.3332/ecancer.2018.873



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation