My ePortfolio Register   

Abstract | Full HTML Article | PDF ecancer 11 763 /

Clinical Study

Breast cancer in Angola, molecular subtypes: a first glance

Purpose: The aim of this study was to investigate the breast cancer (BC) molecular subtypes according to its surrogate immunohistochemistry (IHC) markers. We conducted a preliminary study, to correlate the clinical pathological profiles and molecular subtypes of breast cancer in Luanda, Angola.

Methods: From January 2011 to 30 December 2014, 140 consecutive cases of microscopically confirmed invasive breast carcinoma were classified regarding histology and IHC (ER, PR, HER2, and Ki-67). Surrogate molecular subtypes were classified according to ESMO recommendations.

Results: All patients were female; the median age was 47 years (24–84 years). Invasive carcinoma NST was the most common type (91.4%) and grade 2 was prevalent (70.7%). Most tumours were locally advanced (stage III – 65% and stage IV – 3.6%). In 140 studied cases, 74 (52.8%) malignancies were hormone receptor positive; 25.7% were luminal A like, 19.3% luminal B and HER2 negative like, 7.9%
luminal B and HER2-positive like, 15.7% HER2 positive, and 31.4% were triple negative.

Conclusion: Women’s BC in Luanda-Angola is diagnosed at a young age and at an advanced stage. The two predominant molecular subtypes are HR positive and triple negative. The percentage of HER2-positive BC cases was high. Determining the molecular subtype using surrogate IHC markers has important treatment and prognostic implications for Angolan women with BC. There is an urgent need to
study a prospective BC series in order to confirm the present results.

Keywords: breast carcinoma, Angola, hormone receptors, molecular subtypes

Loading Article Metrics ... Please wait

Author interviews

Dr Fernando Miguel

Angolan Institute of Cancer Control, Luanda, Angola

Related articles

Research: Oncoplastic surgery for the conservative treatment of breast cancer in Perú’s National Cancer Institute

Abstract | Full Article | PDF Published: 01 Mar 2018 /

Case Report: Palliative hysterectomy for vaginal bleeding from breast cancer metastatic to the uterus

Abstract | Full Article | PDF Published: 14 Feb 2018 /

Case Report: Secondary breast cancer after Hodgkin lymphoma: a case report and literature review

Abstract | Full Article | PDF Published: 14 Feb 2018 /

Short Communication: InforMD: a new initiative to raise public awareness about breast density

Abstract | Full Article | PDF Published: 06 Feb 2018 /

Research: Knowledge and attitude of women regarding breast cancer screening tests in Eastern Iran

Abstract | Full Article | PDF Published: 05 Feb 2018 /

Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence