Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 11 751 / https://doi.org/10.3332/ecancer.2017.751

Review

Hypoxia-inducible tumour-specific promoters as a dual-targeting transcriptional regulation system for cancer gene therapy

Transcriptional targeting is the best approach for specific gene therapy. Hypoxia is a common feature of the tumour microenvironment. Therefore, targeting gene expression in hypoxic cells by placing transgene under the control of a hypoxia-responsive promoter can be a good strategy for cancer-specific gene therapy. The hypoxia-inducible gene expression system has been investigated more in suicide gene therapy and it can also be of great help in knocking down cancer gene therapy with siRNAs. However, this system needs to be optimised to have maximum efficacy with minimum side effects in normal tissues. The combination of tissue-/tumour-specific promoters with HRE core sequences has been found to enhance the specificity and efficacy of this system. In this review, hypoxia-inducible gene expression system as well as gene therapy strategies targeting tumour hypoxia will be discussed. This review will also focus on hypoxia-inducible tumourspecific promoters as a dual-targeting transcriptional regulation systems developed for cancer-specific gene therapy.

Keywords: hypoxia, hypoxia-responsive element (HRE), transcriptional targeting

Categories:

Breast R&D Biology

Loading Article Metrics ... Please wait

Related articles

Review: Postoperative radiotherapy after nipple- or skin-sparing mastectomy: a review of recent institutional and pooled data

Abstract | Full Article | PDF Published: 11 May 2018 / https://doi.org/10.3332/ecancer.2018.834

Review: Aggressive breast fibromatosis following augmentation mastoplasty: a series of case reports

Abstract | Full Article | PDF | Spanish Published: 11 May 2018 / https://doi.org/10.3332/ecancer.2018.833

Research: Nursing intervention in women who developed lymphedema after undergoing a modified radical mastectomy: a pre-experimental study

Abstract | Full Article | PDF | Spanish Published: 19 Apr 2018 / https://doi.org/10.3332/ecancer.2018.827

Research: Evidence on the cost of breast cancer drugs is required for rational decision making

Abstract | Full Article | PDF Published: 16 Apr 2018 / https://doi.org/10.3332/ecancer.2018.825

Review: Adipose tissue stem cells in regenerative medicine

Abstract | Full Article | PDF | Spanish Published: 28 Mar 2018 / https://doi.org/10.3332/ecancer.2018.822



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence