My ePortfolio Register   

Abstract | Full HTML Article | PDF | Portuguese ecancer 10 681 /


Phosphoethanolamine and the danger of unproven drugs

The use of unproven forms of therapy in cancer treatment is very common. In Brazil, the distribution by researchers to patients of an investigational agent called phophoethanolamine (PHOS) has led to a widely publicized scientific scandal. PHOS is a precursor to components of the cell membrane, with some published pre-clinical studies suggesting cytotoxic activity in cancer cells. The willingness of courts and of legislators to guarantee access to PHOS in spite of the lack of any clinical data and against the recommendations of scientific and medical organisations underscores the risks that unproven agents pose to regulatory authorities, health care systems and patients, and bears resemblance to other cases such as the controversy surrounding the approval of zidovudine for AIDS treatment by the FDA.

Keywords: phosphoethanolamine, cancer, science, Brazil, ethics

Loading Article Metrics ... Please wait

Related articles

Review: Cystic brain metastases in ALK-rearranged non-small cell lung cancer

Abstract | Full Article | PDF Published: 14 Mar 2018 /

Research: Oncoplastic surgery for the conservative treatment of breast cancer in Perú’s National Cancer Institute

Abstract | Full Article | PDF Published: 01 Mar 2018 /

Research: Knowledge and attitude of women regarding breast cancer screening tests in Eastern Iran

Abstract | Full Article | PDF Published: 05 Feb 2018 /

Research: The mortality-incidence ratio as an indicator of five-year cancer survival in metropolitan Lima

Abstract | Full Article | PDF | Spanish Published: 18 Jan 2018 /

Review: Natural history of castration-resistant prostate cancer in sub-Saharan African black men: a single-centre study of Nigerian men

Abstract | Full Article | PDF Published: 16 Jan 2018 /

Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence