Our website uses cookies to improve your on-site experience. By using the website, cookies are being used as described in our Policy Document
Warning: To log in you will need to enable cookies and reload the page (Policy Document)
My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 1 48 / https://doi.org/10.3332/ecancer.2007.48

Research

[18F] FDG uptake: pay attention to candies

[18F]Fluorodeoxyglucose ([18F]FDG) is a positron emission radiotracer whose biodistribution is similar to glucose. The similar biodistribution of [18F]FDG and glucose in the human body requires a fasting condition for at least six hours prior to performing a [18F]FDG positron emission tomography ([18F]FDG PET) study.

In human studies, FDG PET images, in either the fasting state or the glucose-loaded state, have demonstrated that [18F]FDG uptake is decreased in the tumour, and thus the PET image quality is impaired, when plasma glucose levels are increased. All these results suggest that patients should fast before FDG PET studies, and their plasma glucose concentration needs to be considered when assessing tumour glucose metabolism. However, for lymphomatous disease, the data are contradictory and there are reports that insulin does not induce major changes in glucose uptake of lymphomatous tissue.

Here, we report two cases of lymphoma in which [18F]FDG PET/computed tomography ([18F]FDG PET/CT) was used for chemotherapy response evaluation. In both cases, initial [18F]FDG PET/CT scans were negative for neoplastic lesions but showed increased and diffuse FDG uptake in muscles. This led us to investigate better the importance of a fasting condition. A second [18F]FDG PET/CT performed 3–4 days later revealed pathological uptake in the lymphomatous lesions in both cases.

We demonstrate the importance of a euglycemic state before [18F]FDG administration, and that a fasting period of at least six hours is required prior to administration.

Keywords: [18F]Fluorodeoxyglucose ([18F]FDG) is a positron emission radiotracer whose biodistribution is similar to glucose. The similar biodistribution of [18F]FDG and glucose in human body justify the fasting condition of, at least, 6 hours required to perform a

Loading Article Metrics ... Please wait

Related articles

Review: Non-hormonal strategies for managing menopausal symptoms in cancer survivors: an update

Abstract | Full Article | PDF Published: 11 Mar 2019 / https://doi.org/10.3332/ecancer.2019.909

Case Report: Laser thermal ablation to treat a recurrent soft-tissue sarcoma of the leg: a case report

Abstract | Full Article | PDF Published: 05 Mar 2019 / https://doi.org/10.3332/ecancer.2019.908

Review: Petroclival meningiomas: radiological features essential for surgeons

Abstract | Full Article | PDF Published: 05 Mar 2019 / https://doi.org/10.3332/ecancer.2019.907

Research: Younger age and previous exposure to radiation therapy are correlated with the severity of chemotherapy-induced thrombocytopenia

Abstract | Full Article | PDF Published: 26 Feb 2019 / https://doi.org/10.3332/ecancer.2019.906

Review: The use of intravesical BCG in urothelial carcinoma of the bladder

Abstract | Full Article | PDF Published: 26 Feb 2019 / https://doi.org/10.3332/ecancer.2019.905



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation