Concomitant use of antibiotics and immune checkpoint inhibitors in patients with solid neoplasms

Share :
Published: 15 May 2020
Views: 1279
Rating:
Save
Dr Akhil Kapoor - Tata Memorial Center, Mumbai, India

Dr Akhil Kapoor speaks to ecancer about his article on a study looking at the concomitant use of antibiotics and immune checkpoint inhibitors in patients with solid neoplasms.

He explains that this was a retrospective audit of a prospectively collected database of patients who had received ICI for advanced solid tumours in any line between August 2015 and November 2018 at Tata Memorial Hospital in Mumbai.

Dr Kapoor reports that patients who received antibiotics for more than 10 days had an OS of 2.8 months, compared with 8.8 months for patients who received less than 10 days of antibiotics.

He explains that this shows that a longer duration of antibiotics led to poorer outcomes.

You can read the article published in ecancermedicalscience here.

Related Videos

Cabozantinib shows clinically meaningful improvement in advanced neuroendocrine tumours

Dr Jennifer Chan - Dana-Farber Cancer Institute, Boston, USA
Cabozantinib shows clinically meaningful improvement in advanced neuroendocrine tumours ( Dr Jennifer Chan - Dana-Farber Cancer Institute, Boston, USA )
7 Nov 2023

Selinexor, bortezomib and dexamethasone shows PFS benefit for multiple myeloma

Dr Maria-Victoria Mateos - University Hospital Salamanca, Salamanca, Spain
Selinexor, bortezomib and dexamethasone shows PFS benefit for multiple myeloma ( Dr Maria-Victoria Mateos - University Hospital Salamanca, Salamanca, Spain )
19 Jun 2023

First-line NALIRIFOX shows improvement in OS and PFS in metastatic pancreatic cancer

Prof Eileen M O’Reilly - Memorial Sloan Kettering Cancer Center, New York City, USA
First-line NALIRIFOX shows improvement in OS and PFS in metastatic pancreatic cancer ( Prof Eileen M O’Reilly - Memorial Sloan Kettering Cancer Center, New York City, USA )
15 Jun 2023

Amivantamab shows robust efficacy in post-platinum therapy patients with EGFR Ex20ins NSCLC

Prof Nicolas Girard - Institut Curie, Paris, France
Amivantamab shows robust efficacy in post-platinum therapy patients with EGFR Ex20ins NSCLC ( Prof Nicolas Girard - Institut Curie, Paris, France )
11 Apr 2023

Four chemo cycles given with durvalumab and tremelimumab optimise response and tumour shrinkage in patients with mNSCLC

Dr Niels Reinmuth - University of Muenster, Gauting, Germany
Four chemo cycles given with durvalumab and tremelimumab optimise response and tumour shrinkage in patients with mNSCLC ( Dr Niels Reinmuth - University of Muenster, Gauting, Germany )
6 Apr 2023

CodeBreaK 200 shows sotorasib to be a more tolerable treatment option for patients with pretreated, KRASG12C-mutated advanced NSCLC

Dr David Waterhouse - Dana-Farber Cancer Institute, Boston, USA
CodeBreaK 200 shows sotorasib to be a more tolerable treatment option for patients with pretreated, KRASG12C-mutated advanced NSCLC ( Dr David Waterhouse - Dana-Farber Cancer Institute, Boston, USA )
6 Apr 2023

Final data from phase II study of eftilagimod alpha and pembro in PD-1/PD-L1 inhibitors resistant second line metastatic NSCLC

Dr Margarita Majem Tarruella - Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Final data from phase II study of eftilagimod alpha and pembro in PD-1/PD-L1 inhibitors resistant second line metastatic NSCLC ( Dr Margarita Majem Tarruella - Hospital de la Santa Creu i Sant Pau, Barcelona, Spain )
5 Apr 2023

Pembro monotherapy for participants with BCG–unresponsive HR NMIBC shows anti-tumour activity

Prof Andrea Necchi - The Vita-Salute San Raffaele University, Milan, Italy
Pembro monotherapy for participants with BCG–unresponsive HR NMIBC shows anti-tumour activity ( Prof Andrea Necchi - The Vita-Salute San Raffaele University, Milan, Italy )
16 Mar 2023

Latest in PARP inhibitors and combination therapies for prostate cancer

Dr Dan George, Prof Noel Clarke, Dr Friederike Schlurmann and Prof Eleni Efstathiou
Latest in PARP inhibitors and combination therapies for prostate cancer ( Dr Dan George, Prof Noel Clarke, Dr Friederike Schlurmann and Prof Eleni Efstathiou )
19 Feb 2023