Dr Fabiana Gregucci speaks to ecancer about the long-term single-institution clinical outcomes for locally recurrent breast cancer patients treated with a second breast-conserving surgery and intraoperative radiotherapy.

The study explores management strategies for locally recurrent breast cancer, emphasizing patient preference for breast conservation.

A pilot program since 2012 offers a second breast-conserving treatment with intraoperative radiation.

Involving 171 patients, the study shows that careful selection can yield favourable outcomes, with low local recurrence risk and improved quality of life.

Future research aims to refine patient selection and validate these findings.