The meeting is designed to optimise opportunities for productive discussion, interaction, and collaboration. Conference talks and discussions will center on developing actionable mechanistic knowledge of DNA replication, transcription and repair stress responses and their inflammation impacts suitable to guide cancer research and intervention. A focus will be on leveraging the synthetic lethality concept for DDR defects. Talks will include emerging basic and clinical findings, cutting-edge trans-disciplinary methodologies and structural and mechanistic insights for dynamic complexes.