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SABCS 2010 /
Understanding stem cells to get abreast of breast cancer

8th - 12th Dec 2010

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Published: 19.01.11
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Prof Geoff Lindeman – The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia

Prof Lindeman talks to ecancertv at the 2010 San Antonio Breast Cancer Symposium about how steroid hormones regulate breast function at a cellular level, and the role they play in breast cancer. It was discovered that the stem cell is profoundly sensitive to hormone signalling, despite stem cells lacking hormone receptors. It turns out that the protein ‘RANK ligand’ is key in switching on stem cells in response to hormones . Thus RANK ligand inhibitors could be used to impede tumour function or even prevent new breast cancers. Prof Lindeman also discusses the abstract “steroid hormone regulation of mammary stem cell function” he presented. It was discovered, by looking at BRCA-1 mutation carriers, that the daughter of the stem cell, ‘the luminal progenitor cell’, gives rise to basal-like tumours, This luminal progenitor cell may in turn provide a target for a new drugs, offering potential for a new treatment for basal like breast cancer.

Previous conferences: highlights



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation