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CFS 2011 /
Link between obesity and breast cancer explained?

20th May 2011

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Published: 24.11.11
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Dr Andrew Dannenberg – Weill Cornell Cancer Center, New York, USA

Dr Andrew Dannenberg speaks on the link between obesity and breast cancer at the Chemotherapy Foundation Symposium.

Dr Dannenberg explains how obesity is a risk factor in hormone receptor positive breast cancer in postmenopausal women and that obesity can lead to a worse outcome for women with breast cancer.  Taking this fact Dr Dannenberg began a study using mice and discovered an inflammatory process that occurs in the mammary tissue.

This process could explain the link between obesity and breast cancer, but this data is speculative, as it has only taken place in mice.  In a human study, the same histological lesions, called CLS-B, or crown like structure of the breast, that occur in mice also occur women.  The correlation in the data was that women with a high Body Mass Index, BMI, were far more likely to have these lesions and more severe cases.  The study also examined the genetic links between breast cancer and obesity.

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Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation