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2018 ASCO Annual Meeting /
Dabrafenib halts growth of low-grade paediatric glioma

1st - 5th Jun 2018

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Published: 04.06.18
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Dr Mark Kieran - Dana Farber Cancer Institue, Boston, USA

Dr Kieran speaks with ecancer at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago about results from a phase I/IIa study of dabrafenib in paediatric patients with V600 BRAF mutations in relapsed/refractory low grade glioma.

He outlines the staging of the trial, from dose determination in the phase I setting to subsequent treatment, noting variability in patients ± 12 years old.

Dr Kieran describes the limitation and even shrinkage of patients tumours as highly encouraging, with limited toxicity beyond skin irritation as a BRAF associated toxicity.

ecancer's filming has been kindly supported by Amgen through the ecancer Global Foundation. ecancer is editorially independent and there is no influence over content.

Previous conferences: highlights



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

ecancer Global Foundation