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Crizotinib for advanced papillary renal cell carcinoma with MET mutations or amplification

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Published: 09.02.18
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Prof Patrick Schöffski - The Katholieke Universiteit Leuven, Leuven, Belgium

Prof Schöffski speaks with ecancer at the 2018 ASCO Genitourinary Cancers Symposium about the final results of the CREATE phase II trial, looking at the effect of crizotinib on disease control in patient with advanced papillary renal cell carcinoma type 1 (PRCC1) with MET mutations or amplification.

He describes the few MET patients had a good objective response rate (ORR) to crizotinib (50%) with good PFS.

The MET- patients responded more sporadically with lower ORR and PFS. 

Therefore crizotinib could be suitable for those PRCC1 patients with MET mutations in tumour tissue.

Also, the sporadic results in patients with MET- mutations suggests other alterations of MET signalling - this could mean there is still a way for these patients to receive benefits from crizotinib.

The results are promising, however PRCC1 is such a rare disease that it will be difficult to achieve a large enough patient cohort for a definitive trial.  

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