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Radium-223 for bone predominant metastatic castration resistant prostate cancer

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Published: 08.02.18
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Dr Andrew Armstrong - Duke University School of Medicine, Durham, USA

Dr Armstrong speaks with ecancer at the 2018 ASCO Genitourinary Cancers Symposium about how he hypothesised that prostate cancer osteomimicry, a form of epithelial plasticity leading to an osteoblastic phenotype, may contribute to the intralesional deposition of radium-223 and subsequent irradiation of the tumour microenvironment.

He goes on to discuss a pharmacodynamic study that was conducted of radium-223 in men with bone predominant metastatic castration resistant prostate cancer to investigate genomic and phenotypic alterations in circulating tumour cells, ctDNA, and metastases. 

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