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Mutational landscapes in pregnant and non-pregnant breast cancer

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Published: 12.05.17
Views: 583

Prof Sibylle Loibl - German Breast Cancer Group, Frankfurt, Germany

Prof Loibl speaks with ecancer at IMPAKT 2017 about the differing genetic backgrounds and susceptibilities of breast cancer in patients who are pregnant.

She describes results from next-generation sequencing of samples, compared to data in The Cancer Genome Atlas, noting that the samples assessed were taken from much younger women.

Among the differences in gene expression, Prof Loibl highlights difference in PI3K and p53 mutation levels.

Prof Loibl summarises treatment schedules for pregnant breast cancer patients, cautioning against under-treatment of aggressive tumours and over-treatment of HR2 patients.

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