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Genome stability in potentially immortal planarian stem cells

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Published: 27.04.17
Views: 823
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Sounak Sahu - University of Oxford, Oxford, UK

Sounak Sahu speaks with ecancer at the 1st Cancer Research @ Bath Symposium about the use of planarian worms as a model of stem cell stability under DNA damage.

Planarian worms, which can be cut into over 100 pieces which will each regenerate into a whole worm, can resist significant amounts of ionising radiation, and their management of DNA repair pathways are of clinical interest alongside their telomeric maintenance.

Sahu considers other animal models with similar radioresistance, and considers how identifying genes involved in the pluripotency of adult stem cells could lead to further research. 

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