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Mechanisms of resistance in triple negative breast cancer

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Published: 24.03.17
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Prof Sherene Loi - Peter MacCallum Cancer Centre, Melbourne, Australia

Prof Loi speaks with ecancer at 2017 St. Gallen International Breast Cancer Conference about the oncogenic pathways upregulated in triple negative breast cancer, which can be highly resistant to chemotherapy.

She highlights how genome sequencing has unveiled a patchwork of heterogeneity in tumours, with gene replication and a varied sea of clonotypes which leave targeted or immune therapies unable to deliver significant damage.

Prof Loi hopes that further understanding of these mechanisms will aid in developing combinations of therapies for the disease.

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