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Functional characterisation of therapeutic targets through comparative pharmacology

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Published: 22.12.15
Views: 1403
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Dr Igor Vivanco - Institute Of Cancer Research, London, UK

Dr Vivanco talks to ecancer at the 3rd EurocanPlatform Translational Research Course about how researchers are trying to determine the basic mechanism of how targeted drugs elicit the response they have in cancer cells. He also discusses comparative pharmacology: the detailed comparison and characterization of multiple selective pharmacological agents of a defined target with distinct mechanisms of action.

He describes how they’re currently trying to work on a number of Phase I clinical trials and learn why most trials tend to fail, as well as his work on the response to EGFR inhibitors in EGFR-mutant glioblastoma.

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