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Sugar in western diets increases risk for breast cancer tumours and metastasis

The high amounts of dietary sugar in the typical Western diet may increase the risk of breast cancer and metastasis to the lungs, according to a study at The University of Texas MD Anderson Cancer Center.

The findings, published in the online issue of Cancer Research, demonstrated dietary sugar's effect on an enzymatic signalling pathway known as 12-LOX (12-lipoxygenase).

"We found that sucrose intake in mice comparable to levels of Western diets led to increased tumour growth and metastasis, when compared to a non-sugar starch diet," said Peiying Yang, Ph.D., assistant professor of Palliative, Rehabilitation, and Integrative Medicine.

"This was due, in part, to increased expression of 12-LOX and a related fatty acid called 12-HETE."

Previous epidemiological studies have shown that dietary sugar intake has an impact on breast cancer development, with inflammation thought to play a role.

"The current study investigated the impact of dietary sugar on mammary gland tumour development in multiple mouse models, along with mechanisms that may be involved," said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine.

"We determined that it was specifically fructose, in table sugar and high-fructose corn syrup, ubiquitous within our food system, which was responsible for facilitating lung metastasis and 12-HETE production in breast tumours."

Cohen added that the data suggested that dietary sugar induces 12-LOX signalling to increase risks for breast cancer development and metastasis.

Identifying risk factors for breast cancer is a public health priority, say the authors.

The researchers state that moderate sugar consumption is critical, given that the per capita consumption of sugar in the U.S. has surged to over 100 lbs. per year and an increase in consumption of sugar-sweetened beverages has been identified as a significant contributor to an epidemic of obesity, heart disease and cancer worldwide.

"Prior research has examined the role of sugar, especially glucose, and energy-based metabolic pathways in cancer development," said Yang.

"However, the inflammatory cascade may be an alternative route of studying sugar-driven carcinogenesis that warrants further study."

No previous studies have investigated the direct effect of sugar consumption on the development of breast cancer using breast cancer animal models or examined specific mechanisms, she added.

The MD Anderson team conducted four different studies in which mice were randomised to different diet groups and fed one of four diets.

At six months of age, 30 percent of mice on a starch-control diet had measurable tumours, whereas 50 to 58 percent of the mice on sucrose-enriched diets had developed mammary tumours.

The study also showed that numbers of lung metastases were significantly higher in mice on a sucrose- or a fructose-enriched diet, versus mice on a starch-control diet.

"This study suggests that dietary sucrose or fructose induced 12-LOX and 12-HETE production in breast tumour cells in vivo," said Cohen.

"This indicates a possible signalling pathway responsible for sugar-promoted tumour growth in mice. How dietary sucrose and fructose induces 12-HETE and whether it has a direct or indirect effect remains in question."

The study team believes that the mechanism by which dietary sucrose or fructose affects breast tumour growth and metastasis, especially through the 12-LOX pathways, warrants further investigation.

SourceUniversity Of Texas M. D. Anderson Cancer Center



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