Supporting oncology professionals through education

The content on this site is intended for healthcare professionals only

ecancermedicalscience

Submit article
Articles
Editorials
Special issues
Author interviews
https://doi.org/10.3332/ecancer.2015.525
Abstract | Full Article | PDF

Research

Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

22 Apr 2015
Alok Mishra, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

Related Articles

2179-enhancing-breast-cancer-prediction-using-a-customised-neural-network-with-oversampling-and-feature-selection-on-mizo-population-germline-datasets
Brindha Senthil Kumar, Ponnagoundanpudur Sundaramoorthy Kirit, Nachimuthu Senthil Kumar, Shanmuganandam Sumathi, Samuel Lalhruaizela, Lal Hruaitluanga, Lal Hmingliana
2181-delay-in-diagnosis-and-treatment-of-patients-with-oral-cancer-seeking-treatment-in-a-public-hospital-in-india-a-cross-sectional-study
Parth Sharma, Mongjam Meghachandra Singh, Amod Laxmikant Borle, Disha Agrawal, Anurita Srivastava, Ravi Meher
2177-a-retrospective-analysis-of-the-clinico-epidemiological-features-and-treatment-outcomes-of-renal-cell-carcinoma-at-the-clinical-oncology-department-at-ain-shams-university-in-egypt
Zizit Hamdi Mohammed El-Shahawi, Soheir Sayed Ismail, Lamia Moustafa Ahmed, Nesreen Ahmed Mosalam
2178-treatment-and-outcomes-of-people-with-bladder-cancer-in-armenia-a-retrospective-hospital-based-study
Samvel Bardakhchyan, Sona Karamyan, Hovsep Gharadaghyan, Davit Zohrabyan, Liana Safaryan, Armen Avagyan, Lilit Harutyunyan, Vardan Bardakhchyan, Amalya Sargsyan, Mariam Mailyan, Mariam Sargsyan, Elen Baloyan, Nune Karapetyan, Marine Rushanyan, Gohar Mkrtchyan, Sahak Azizyan, Martin Harutyunyan, Gevorg Tamamyan
2175-retrospective-analysis-of-the-surgical-management-of-breast-cancer-at-the-yaounde-general-hospital
Mouthe Jimmy, Ndah Akelekeh, Metogo Junie, Akelekeh Aponglen Ndah, Bah Felix Juweh, Boah-Ju Bill Brisbane, Kemfang Ngowa
2170-efficacy-of-pembrolizumab-and-oncolytic-viral-therapy-in-stage-iii-esophageal-cancer-a-narrative-review
Rajsinh Bhosale, Lamiya Pirzada, Safiyyah Khan, Aqsa Zainab, Shravya Subashini Sivaramakrishnan, Areeba Mariam Mehmood, Pawan Sapkota Upadhya

More from ecancer

Register with ecancer to receive our newsletter

Register here

Explore patient resources at ecancerpatient

Visit site

Find out more about ecancer and the work we do

About ecancer

Support ecancer's work by making a donation