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https://doi.org/10.3332/ecancer.2015.525

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Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

22 Apr 2015

Alok Mishra, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

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1991-colorectal-cancer-care-in-tanzania-an-evaluation-of-clinical-characteristics-treatment-patterns-and-quality-metrics-at-a-national-cancer-referral-hospital

Research: Colorectal cancer care in Tanzania: an evaluation of clinical characteristics, treatment patterns and quality metrics at a national cancer referral hospital

Beatrice P Mushi, Summaiya Haddadi, Alita Mrema, Jerry Ndumbalo, Nanzoke Mvungi, Msiba Selekwa, Julius Mwaiselage, Larry Akoko, Yona Ringo, Rohan Luhar, Rebecca DeBoer, Katherine Van Loon, Elia Mmbaga, Geoffrey C Buckle

16 Sep 2025

https://doi.org/10.3332/ecancer.2025.1991

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1987-leading-the-fight-against-liver-cancer-in-sub-saharan-africa-developing-the-first-multidisciplinary-liver-tumour-board-in-tanzania

Research: Leading the fight against liver cancer in Sub-Saharan Africa: developing the first multidisciplinary liver tumour board in Tanzania

Ally H Mwanga, Erick M Mbuguje, Jeanine Justiniano, Balowa Musa, Nashivai Kivuyo, Daniel W Kitua, Eva Uiso, Andrew Swallow, Edith Kimambo, Azza Naif, Deogratius B Mwanakulya, Swaleh Pazi, Advera Ngaiza, Seif Wibonela, Behnam Shaygi, Cameron E Gaskill

15 Sep 2025

https://doi.org/10.3332/ecancer.2025.1987

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1988-feasibility-and-impact-of-knowledge-based-automated-radiotherapy-treatment-planning-in-low-and-middle-income-countries

Research: Feasibility and impact of knowledge-based automated radiotherapy treatment planning in low- and middle-income countries

Awusi Kavuma, Solomon Kibudde M.Med, Yao Hao, Baozhou Sun

15 Sep 2025

https://doi.org/10.3332/ecancer.2025.1988

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1981-bridging-gaps-in-breast-cancer-care-a-breast-cancer-care-quality-index-to-improve-outcomes-worldwide

Policy: Bridging gaps in breast cancer care: a Breast Cancer Care Quality Index to improve outcomes worldwide

Eduardo Cazap, Benjamin O Anderson, Giuseppe Curigliano, Sandeep Sehdev, Fatima Cardoso, Ana Rita Gonzalez, Emad Shash, Cheng-Har Yip, André Mattar, Yanin Chavarri-Guerra, Miriam Mutebi, Yongmei Yin, João Victor Rocha, Ilaria Lucibello, Namita Srivastava

1 Sep 2025

https://doi.org/10.3332/ecancer.2025.1981

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