My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 8 485 / DOI: 10.3332/ecancer.2014.485

Clinical Study

Repurposing drugs in oncology (ReDO)—Cimetidine as an anti-cancer agent

Cimetidine, the first H2 receptor antagonist in widespread clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical and clinical studies for a number of different cancer types. These data are summarised and discussed in relation to a number of distinct mechanisms of action. Based on the evidence presented, it is proposed that cimetidine would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of cimetidine as an anti-cancer therapeutic is warranted. Furthermore, there is compelling evidence that cimetidine administration during the peri-operative period may provide a survival benefit in some cancers. A number of possible combinations with other drugs are discussed in the supplementary material accompanying this paper.

Keywords: Drug repurposing, cimetidine, immunostimulant, ReDO project

Loading Article Metrics ... Please wait

Related articles

Conference Report: Highlights from the 2016 WIN Symposium, 27–29 June 2016, Paris: personalised therapy beyond next-generation sequencing

Abstract | Full Article | PDF Published: 24 Aug 2016 / DOI: 10.3332/ecancer.2016.669

Conference Report: Children’s palliative care now! Highlights from the second ICPCN conference on children’s palliative care, 18–21 May 2016, Buenos Aires, Argentina

Abstract | Full Article | PDF | Spanish Published: 23 Aug 2016 / DOI: 10.3332/ecancer.2016.667

Review: The role of surgery in advanced epithelial ovarian cancer

Abstract | Full Article | PDF Published: 17 Aug 2016 / DOI: 10.3332/ecancer.2016.666

Case Report: An extremely rare case of a high-grade pleomorphic cardiac sarcoma and likely cerebral metastasis in a young patient

Abstract | Full Article | PDF Published: 15 Aug 2016 / DOI: 10.3332/ecancer.2016.664

Research: Time-dependent image changes after ethanol injection into the pancreas: an experimental study using a porcine model

Abstract | Full Article | PDF Published: 15 Aug 2016 / DOI: 10.3332/ecancer.2016.663



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence