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Abstract | Full HTML Article | PDF ecancer 8 450 / https://doi.org/10.3332/ecancer.2014.450

Case Report

Neuroendocrine carcinoma of the cervix presenting as intractable hyponatremic seizures due to paraneoplastic SIADH—a rare case report and brief review of the literature

Herein is presented an interesting case of small-cell neuroendocrine carcinoma of the cervix which initially manifests as seizures due to hyponatremia caused by paraneoplastic syndrome of inappropriate anti diuretic hormone (SIADH). Awareness of a paraneoplastic syndrome at presentation can lead to early diagnosis and early initiation of treatment. The management is also unique in that it combines treating the paraneoplastic aspects as well as targeting the tumour itself. Multimodality treatment gives the best outcome in this aggressive tumour.

Keywords: neuroendocrine carcinoma (NEC), paraneoplastic syndromes, SIADH

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European Cancer Organisation European Institute of Oncology

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Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

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Cancer Intelligence