Abstract | Full HTML Article | PDF ecancer 6 246 / DOI: 10.3332/ecancer.2012.246

Circulating microRNAs: next-generation biomarkers for early lung cancer detection

F Bianchi, F Nicassio, G Veronesi and PP Di Fiore

Early diagnosis of lung cancer by low-dose computed tomography is an effective strategy to reduce cancer mortality in high-risk individuals. However, recruitment of at-risk individuals with asymptomatic lung cancer still remains challenging. We developed a minimal invasive serum test, based on the detection of circulating microRNAs, which can identify at-risk individuals with asymptomatic early stage nonsmall cell lung carcinomas with 80% accuracy.