My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 11 762 / https://doi.org/10.3332/ecancer.2017.762

Research

Serum biomarkers to predict risk of testicular and penile cancer in AMORIS

Purpose: To evaluate the association between commonly measured serum biomarkers of inflammation and penile and testicular cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study.

Materials and methods: A total of 205,717 subjects had baseline measurements of C-reactive protein, albumin, and haptoglobin. The association between quartiles and dichotomised values of inflammatory markers and penile and testicular cancer risk were analysed by using multivariate Cox proportional hazard models.

Results: A total of 125 men were diagnosed with testicular cancer and 50 with penile cancer during a mean follow-up of 20.3 years. No statistically significant trends were seen between serum inflammatory markers and risk of penile cancer, but higher albumin levels increased the risk of testicular cancer [HR for albumin (g/L): 1.10 (95% CI: 1.03–1.18)]. However, this trend was not observed when using medical cut-offs of albumin.

Conclusions: In the present study, we did not find support for an association between commonly used markers of inflammation and risk of testicular or penile cancer. The role of inflammation may be more complicated and require assessment of more specialised measurements of inflammation in future studies.

Keywords: penile cancer, testicular cancer, serum inflammatory markers, albumin, cohort study, survival analysis

Categories:

Prostate & urology

Loading Article Metrics ... Please wait

Related articles

Conference Report: Highlights from the WIN 2017 Symposium, 26–27 June 2017, Paris, France: ‘Expediting Global Innovation in Precision Cancer Medicine’

Abstract | Full Article | PDF Published: 27 Sep 2017 / https://doi.org/10.3332/ecancer.2017.770

Case Report: Penile melanoma: a 20-Year analysis of six patients at the National Cancer Institute of Peru, Lima

Abstract | Full Article | PDF | Spanish Published: 04 Apr 2017 / https://doi.org/10.3332/ecancer.2017.731

Conference Report: Highlights from the first ecancer–Liga Colombiana contra el Cancer conference, 17–18 November 2016, Bogota, Colombia

Abstract | Full Article | PDF | Spanish Published: 28 Mar 2017 / https://doi.org/10.3332/ecancer.2017.730

Research: The presence of primary circulating prostate cells is associated with upgrading and upstaging in patients eligible for active surveillance

Abstract | Full Article | PDF Published: 10 Jan 2017 / https://doi.org/10.3332/ecancer.2017.711

Conference Report: Biomarkers come of age: PD1 in the frontline and cell cycle therapy swells the ranks of personalised therapy in the European Society of Medical Oncology (ESMO) congress, Copenhagen, 7–10 October 2016

Abstract | Full Article | PDF Published: 16 Dec 2016 / https://doi.org/10.3332/ecancer.2016.703



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence