My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 11 751 / https://doi.org/10.3332/ecancer.2017.751

Review

Hypoxia-inducible tumour-specific promoters as a dual-targeting transcriptional regulation system for cancer gene therapy

Transcriptional targeting is the best approach for specific gene therapy. Hypoxia is a common feature of the tumour microenvironment. Therefore, targeting gene expression in hypoxic cells by placing transgene under the control of a hypoxia-responsive promoter can be a good strategy for cancer-specific gene therapy. The hypoxia-inducible gene expression system has been investigated more in suicide gene therapy and it can also be of great help in knocking down cancer gene therapy with siRNAs. However, this system needs to be optimised to have maximum efficacy with minimum side effects in normal tissues. The combination of tissue-/tumour-specific promoters with HRE core sequences has been found to enhance the specificity and efficacy of this system. In this review, hypoxia-inducible gene expression system as well as gene therapy strategies targeting tumour hypoxia will be discussed. This review will also focus on hypoxia-inducible tumourspecific promoters as a dual-targeting transcriptional regulation systems developed for cancer-specific gene therapy.

Keywords: hypoxia, hypoxia-responsive element (HRE), transcriptional targeting

Categories:

Breast R&D Biology

Loading Article Metrics ... Please wait

Related articles

Case Report: Palliative hysterectomy for vaginal bleeding from breast cancer metastatic to the uterus

Abstract | Full Article | PDF Published: 14 Feb 2018 / https://doi.org/10.3332/ecancer.2018.811

Case Report: Secondary breast cancer after Hodgkin lymphoma: a case report and literature review

Abstract | Full Article | PDF Published: 14 Feb 2018 / https://doi.org/10.3332/ecancer.2018.810

Short Communication: InforMD: a new initiative to raise public awareness about breast density

Abstract | Full Article | PDF Published: 06 Feb 2018 / https://doi.org/10.3332/ecancer.2018.807

Research: Knowledge and attitude of women regarding breast cancer screening tests in Eastern Iran

Abstract | Full Article | PDF Published: 05 Feb 2018 / https://doi.org/10.3332/ecancer.2018.806

Research: Diagnostic validity of fine-needle capillary cytology in palpable tumours at the Oncology Institute of Peru

Abstract | Full Article | PDF | Spanish Published: 01 Feb 2018 / https://doi.org/10.3332/ecancer.2018.805



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence