My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 11 712 / https://doi.org/10.3332/ecancer.2017.712

Clinical Study

Study of clinical, haematological and cytogenetic profile of patients with acute erythroid leukaemia

Background: Acute erythroid leukaemia (AEL) is a rare subtype of acute myeloid leukaemia (AML), constituting <5% of all the cases of AML. The World Health Organization (WHO) in 2001 classified AEL into two types: (1) erythroid/myeloid leukaemia which required ≥50% erythroid precursors with ≥20% of the non-erythroid cells to be myeloid blasts and (2) pure erythroleukemia (pEL) with ≥80% erythroblasts. The WHO 2008 classification kept these subcategories, but made erythroleukemia a diagnosis of exclusion. There are very few studies on the clinico haematological and cytogenetic profile of this disease, considering the rarity of its occurrence and poor prognosis.

Materials and methods: This study was done by retrospective analysis of data from 32 case files of patients diagnosed with AEL. Clinical details noted down were the demographic profile, peripheral blood smear details and bone marrow examination details: (1) blasts-erythroblasts and myeloblasts, (2) dysplasia in the cell lineages and (3) cytogenetic abnormalities.

Results: The most common presenting symptom was fever. Pancytopenia at presentation was seen in 81.25% of patients. Dysplasia was observed in bone marrow in 100% of erythroblasts and in 40% of myeloblasts in erythroid/myeloid subtype. In pure myeloid subtype, myeloid and megakaryocytic dysplasias were not obvious. Complex karyotype was noticed only in patients of pEL.

Conclusion: AEL is a rare group of heterogeneous diseases with many neoplastic and non-neoplastic conditions mimicking the diagnosis. The clinical presentation and cytogenetics are also non-specific, presenting additional challenges to the diagnosis.

Keywords: Clinicohematological profile, cytogenetics, acute erythroid leukemia

Categories:

Haematology oncology

Loading Article Metrics ... Please wait

Related articles

Special Issue: Acute myeloid leukaemia at an early age: Reviewing the interaction between pesticide exposure and KMT2A-rerrangments

Abstract | Full Article | PDF Published: 30 Nov 2017 / https://doi.org/10.3332/ecancer.2017.782

Case Report: Use of PEG-asparaginase in monomorphic epitheliotropic intestinal T-cell lymphoma, a disease with diagnostic and therapeutic challenges

Abstract | Full Article | PDF Published: 27 Sep 2017 / https://doi.org/10.3332/ecancer.2017.771

Conference Report: Highlights from the WIN 2017 Symposium, 26–27 June 2017, Paris, France: ‘Expediting Global Innovation in Precision Cancer Medicine’

Abstract | Full Article | PDF Published: 27 Sep 2017 / https://doi.org/10.3332/ecancer.2017.770

Case Report: Deterioration of duodenal lymphangiectasia after radiotherapy for gastric MALT lymphoma

Abstract | Full Article | PDF Published: 11 Jul 2017 / https://doi.org/10.3332/ecancer.2017.752

Conference Report: Highlights from the 58th meeting of the American Society of Haematology, 1–6 December 2016, San Diego, USA

Abstract | Full Article | PDF Published: 09 Mar 2017 / https://doi.org/10.3332/ecancer.2017.725



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence