My ePortfolio Register   
 

Abstract | Full HTML Article | PDF | Spanish ecancer 10 705 / DOI: 10.3332/ecancer.2016.705

Special Issue

Central nervous system metastasis secondary to colorectal cancer: a retrospective cohort study of 20 cases

Introduction: Involvement of the central nervous system (CNS) secondary to colorectal cancer is infrequent and associated with a poor prognosis. Its treatment is extrapolated from metastases of other origins as the information available on this scenario is limited. The goal of this study is to assess the clinical characteristics of a series of patients and determine the results in terms of progression-free survival (PFS) and global survival.

Method: The records of patients with CNS metastasis of colorectal origin who were treated in this facility between the years 2001 and 2016 were reviewed retrospectively.

Results: 20 patients with CNS lesions of this origin were identified. Of these, 45% were male and 55% were female (average age 65.5 years). The histology corresponded to tubular adenocarcinoma in 95% of cases. Around 85% of the patients showed a neurological deficit, and their recursive partitioning analysis (RPA) classifications were 1 in 20%, 2 in 55%, and 3 in 25% of the cases studied. The treatments provided were: holocerebral radiotherapy (45%), stereotactic radiosurgery (25%), surgery followed by holocerebral radiotherapy (25%), and exclusively palliative care (5%). The PFS was 2.6 months from treatment of the CNS lesion, while the median survival was 3.8 months. The survival times for patients receiving different treatments were as follows: surgery plus holocerebral radiotherapy 16.2 months, stereotactic radiotherapy 12 months, and holocerebral radiotherapy 2.4 months (p = 0.003).

Conclusion: The prognosis for patients with metastasis of colorectal origin is poor. The patients treated with surgery or stereotactic radiotherapy can have a greater survival.

Keywords: Colorectal neoplasia, cerebral metastasis, radiosurgery, neurosurgery

Loading Article Metrics ... Please wait

Related articles

Review: Tobacco in post-conflict settings: the case of Iraq

Abstract | Full Article | PDF Published: 28 Apr 2017 / DOI: 10.3332/ecancer.2017.735

Conference Report: Highlights from the 15th St Gallen International Breast Cancer Conference 15–18 March, 2017, Vienna: tailored treatments for patients with early breast cancer

Abstract | Full Article | PDF Published: 07 Apr 2017 / DOI: 10.3332/ecancer.2017.732

Case Report: Penile melanoma: a 20-Year analysis of six patients at the National Cancer Institute of Peru, Lima

Abstract | Full Article | PDF | Spanish Published: 04 Apr 2017 / DOI: 10.3332/ecancer.2017.731

Conference Report: Highlights from the first ecancer–Liga Colombiana contra el Cancer conference, 17–18 November 2016, Bogota, Colombia

Abstract | Full Article | PDF | Spanish Published: 28 Mar 2017 / DOI: 10.3332/ecancer.2017.730

Conference Report: Highlights from the ecancer Future Horizons in Lung Cancer conference, 1–2 September 2016: Focusing on the future of treatment for NSCLC and SCLC

Abstract | Full Article | PDF Published: 23 Mar 2017 / DOI: 10.3332/ecancer.2017.729



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence