My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 10 698 / https://doi.org/10.3332/ecancer.2016.698

Review

The current status of prophylactic femoral intramedullary nailing for metastatic cancer

The most common site for cancer to spread is bone. At post-mortem, bony metastases have been found in 70% of patients dying from breast and prostate cancer. Due to the prevalence of cancer, bone metastasis and the associated management represents a huge burden on NHS resources.

In patients with metastasis, around 56% of these involve the lower limb long bones. Due to the huge forces placed upon long bones during weight bearing, there is a high risk of fracture through areas of metastasis. It is reported that 23% of pathological fractures occur in the femoral subtrochanteric region. This area is subjected to forces up to four times the body weight, resulting in poor union rate for these fractures, and significant morbidity associated with difficulty in mobilising, and in patient nursing.

As cancer treatments improve, the life expectancy in this subgroup of patients is likely to increase. Therefore medium-to-long-term management of these fractures, beyond the palliative, will become essential. We aim to evaluate the current management for metastatic malignant femoral disease, with particular focus on the prophylactic augmentation of diseased femorii using intramedullary nails.

Keywords: metastatic cancer, intramedullary nailing, arthroplasty, internal fixation, pathological fracture, prophylactic nailing

Loading Article Metrics ... Please wait

Related articles

Review: Natural history of castration-resistant prostate cancer in sub-Saharan African black men: a single-centre study of Nigerian men

Abstract | Full Article | PDF Published: 16 Jan 2018 / https://doi.org/10.3332/ecancer.2018.797

Special Issue: Novel devices for implant-based breast reconstruction: is the use of meshes to support the lower pole justified in terms of benefits? A review of the evidence

Abstract | Full Article | PDF Published: 10 Jan 2018 / https://doi.org/10.3332/ecancer.2018.796

Special Issue: Novel techniques for intraoperative assessment of margin involvement

Abstract | Full Article | PDF Published: 10 Jan 2018 / https://doi.org/10.3332/ecancer.2018.795

Special Issue: Update on intraoperative radiotherapy: new challenges and issues

Abstract | Full Article | PDF Published: 10 Jan 2018 / https://doi.org/10.3332/ecancer.2018.793

Conference Report: Highlights from the Inaugural International Cancer Microbiome Consortium Meeting (ICMC), 5–6 September 2017, London, UK

Abstract | Full Article | PDF Published: 20 Dec 2017 / https://doi.org/10.3332/ecancer.2017.791



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence